Palavras-chave
Feridas Malignas
Morfina Tópica
Mama
Cabeça e Pescoço
Cuidados Paliativos
Como Citar
Resumo
Objetivo: Analisar a efetividade da morfina tópica no controle da dor local e na promoção do conforto em pacientes com feridas neoplásicas em mama, cabeça ou pescoço. Método: Ensaio clínico randomizado de fase II, duplo-cego, realizado em centro único. O estudo pretende incluir 106 pacientes com feridas neoplásicas malignas nessas regiões, maiores de 18 anos, com escore mínimo de três na escala numérica de avaliação da dor (0-10). Resultados esperados: Os principais desfechos avaliados serão a intensidade média da dor, alívio médio da dor, escore de conforto, dosagem de morfina sistêmica e incidência/classificação de eventos adversos.Registro: ClinicalTrials.gov (NCT05800834).
Referências
Tam SH, Lai WS, Kao CY, Fang SY. “Maintain Professionalism”: Nurses' Experiences in Caring for Patients with Malignant Fungating Wounds in Taiwan. J Pain Symptom Manage. 2024;68(1):69-77.e1. https://doi.org/10.1016/j.jpainsymman.2024.04.008
Tilley CP, Fu MR, Van Cleeve J, Crocilla BL, Comfort CP. Symptoms of Malignant Fungating Wounds and Functional Performance among Patients with Advanced Cancer: An Integrative Review from 2000 to 2019. J Palliat Med. 2020;23(6):848-862. https://doi.org/10.1089/jpm.2019.0617
Takeda Y, Ishiki H, Oyamada S, Otani H, Maeda I, Yamaguchi T, et al. Symptoms and Prognoses of Patients With Breast Cancer and Malignant Wounds in Palliative Care Units: The Multicenter, Prospective, Observational EASED Study. Am J Hosp Palliat Care. 2024;41(12):1373-1379. https://doi.org/10.1177/10499091231219855
Snelson K, Downe A. Use of topical morphine gel in epidermolysis bullosa wounds—A series of case studies. Int Wound J. 2023;20(6):1954-1959. https://doi.org/10.1111/iwj.14055
Klosko RC, Saphire ML. Topical Morphine Gel as a Systemic Opioid Sparing Technique. J Pain Palliat Care Pharmacother. 2022;36(3):159-165. https://doi.org/10.1080/15360288.2022.2084488
Jansen MMPM, Waas VPHV, Verzijl JM, Burger D. Development of a sterile morphine hydrogel for the local treatment of painful skin ulcers. Eur J Hosp Pharm. 2021;28(6):331-335. https://doi.org/10.1136/ejhpharm-2018-001841
Patel R, Mogoi RO, Ali SK. Topical Lidocaine and Morphine Gel Use for Malignant Wound Pain. J Pain Palliat Care Pharmacother. 2023;37(3):216-217. https://doi.org/10.1080/15360288.2023.2194870
Mao P, Zhang Y, Liu B, Li Y, Chang Y, Zhu M, et al. Effect and safety profile of topical lidocaine on post-surgical neuropathic pain and quality of life: A systematic review and meta-analysis. J Clin Anesth. 2024;92:111219. https://doi.org/10.1016/j.jclinane.2023.111219
Firmino F, Ferreira SADC, Franck EM, Queiroz WMS, Castro DV, Nogueira PC, et al. Malignant Wounds in Hospitalized Oncology Patients: Prevalence, Characteristics, and Associated Factors. Plast Surg Nurs. 2020;40(3):138-144. https://doi.org/10.1097/PSN.0000000000000320
Mehta A, Chai E, Berglund K, Rizzo E, Moreno J, Gelfman LP. Using Admission Karnofsky Performance Status as a Guide for Palliative Care Discharge Needs. J Palliat Med. 2021;24(6):910-913. https://doi.org/10.1089/jpm.2020.0543
Uçar Ö, Çelik S. Comparison of platelet-rich plasma gel in the care of the pressure ulcers with the dressing with serum physiology in terms of healing process and dressing costs. Int Wound J. 2020;17(3):831-841. https://doi.org/10.1111/iwj.13344
Kroenke K, Lam V, Ruddy KJ, Pachman DR, Herrin J, Rahman PA, et al. Prevalence, Severity, and Co-Occurrence of SPPADE Symptoms in 31,866 Patients With Cancer. J Pain Symptom Manage. 2023;65(5):367-377. https://doi.org/10.1016/j.jpainsymman.2023.01.020
Thorpe CS, DeWees TA, Golafshar MA, Bhangoo RS, Vern-Gross TZ, McGee LA, et al. Patient-reported outcomes version of the common terminology criteria for adverse events and quality-of-life linear analogue self-assessment in breast cancer patients receiving radiation therapy: single-institution prospective registry. J Patient Rep Outcomes. 2022;6(1):3. https://doi.org/10.1186/s41687-021-00408-9
Sabater-Gárriz Á, Molina-Mula J, Montoya P, Riquelme I. Pain assessment tools in adults with communication disorders: systematic review and meta-analysis. BMC Neurol. 2024;24(1):66. https://doi.org/10.1186/s12883-024-03539-w
Güzel N, Yava A, Koyuncu A. The Effects of Preoperative Video-Assisted Education on Anxiety and Comfort After Breast Cancer Surgery: Nonrandomized Controlled Study. J Perianesth Nurs. 2024;S1089-9472(24)00035-2. https://doi.org/10.1016/j.jopan.2024.01.017
Froh EB, Brodecki D, McCabe MM. Creation and implementation of a REDCap database demonstrates engagement and impact for a hospital-based center for nursing research and evidence-based practice. J Pediatr Nurs. 2024;78:e175-e179. https://doi.org/10.1016/j.pedn.2024.07.003
Black J, Julier P, Eldridge L, Barber VS. Streamlining electronic reporting of serious adverse events (SAEs) using the REDCap data collection system: the eSAE Project. Trials. 2024;25(1):503. https://doi.org/10.1186/s13063-024-08317-0
Armijo-Olivo S, Barbosa-Silva J, de Castro-Carletti EM, de Oliveira-Souza AIS, Pelai EB, Mohamad N, et al. Intention-to-Treat Analysis in Clinical Research: Basic Concepts for Clinicians. Am J Phys Med Rehabil. 2024;103(9):845-857. https://doi.org/10.1097/PHM.0000000000002444
Ouyang Y, Taljaard M, Forbes AB, Li F. Maintaining the validity of inference from linear mixed models in stepped-wedge cluster randomized trials under misspecified random-effects structures. Stat Methods Med Res. 2024;33(9):1497-1516. https://doi.org/10.1177/09622802241248382
Mihaicuta S, Udrescu L, Militaru A, Nadasan V, Tiotiu A, Bikov A, et al. Multivariate analysis and data mining help predict asthma exacerbations. J Asthma. 2024;61(6):608-618. https://doi.org/10.1080/02770903.2023.2297366
Medronho RA, Bloch KV, Luiz RR, Werneck GL. Epidemiologia. 3a ed. Rio de Janeiro: Atheneu; 2025.
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