Palavras-chave
Compostos Fitoquímicos
Fitoterapia
Produtos Biológicos
Candidíase Vulvovaginal
Como Citar
Resumo
Objetivo: Mapear os diferentes tipos de estudos e métodos usados para investigar a atividade antimicrobiana e antifúngica do Allium sativum L. (alho). Método: Seguindo a metodologia do JBI, será realizada uma análise de escopo que considerará estudos que envolvam tanto animais quanto seres humanos, abrangendo contextos geográficos e culturais. Serão incluídos estudos, como os experimentais, quasiexperimentais, observacionais e descritivos, bem como literatura cinzenta, sem restrição de idioma. Para a busca dos estudos, serão utilizadas bases de dados como Web of Science, PubMed, Scopus, ScienceDirect, Epistemonikos, Embase, Cochrane Library, CINAHL, Biblioteca Digital Brasileira de Teses e Dissertações, bem como as referências de estudos relevantes. Serão incluídos estudos publicados e não publicados dos últimos anos. Dois revisores independentes serão responsáveis pela seleção dos títulos e resumos, pela leitura completa dos textos e pela extração dos dados, empregando uma ferramenta baseada no protocolo previamente publicado intitulado "Wound-healing properties of Stryphnodendron adstringens (barbatimão) in skin and mucosa injuries: a scoping review protocol". Caso seja necessário, um terceiro revisor poderá ser adicionado ao processo. Para melhor visualização e interpretação dos resultados, estes serão exibidos em forma de mapa, diagrama ou tabela.
Referências
Nasir A, Fatma G, Neshat N, Ahmad MA. Pharmacological and therapeutic attributes of garlic (Allium sativum Linn.) with special reference to Unani medicine - a review [Internet]. Journal of Medicinal Plants Studies. 2020 [citado 2024 Maio 05];8(3):06-09. Disponível em: https://www.plantsjournal.com/archives/2020/vol8issue3/PartA/8-2-30-178.pdf
Savairam VD, Patil NA, Borate SR, Ghaisas MM, Shete RV. Allicin: a review of its important pharmacological activities. Pharmacological research. Modern Chinese medicine. 2023;8:100283. https://doi.org/10.1016/j.prmcm.2023.100283
Jikah AN, Edo GI, Makia RS, Yousif E, Gaaz TS, Isoje EF, et al. A review of the therapeutic potential of sulfur compounds in Allium sativum. Measurement: Food. 2024;15:100195. https://doi.org/10.1016/j.meafoo.2024.100195
El-Saber Batiha GES, Magdy Beshbishy A, G Wasef L, Elewa YHA, A Al-Sagan A, Abd El-Hack ME, et al. Chemical constituents and pharmacological activities of garlic (Allium sativum L.): a review. Nutrients. 2020;12(3):872. https://doi.org/10.3390/nu12030872
El Mahi F, Hasib A, Boulli A, Boussadda L, Abidi O. Phytochemical compounds and pharmacologicalactivities of garlic (Allium sativum L.): a review. Moroccan Journal of Public Health. 2021;3(2):47-64. https://doi.org/10.34874/PRSM.mjph-vol3iss2.30290
Nakamoto M, Kunimura K, Jun-Ichiro S, Kodera Y. Antimicrobial properties of hydrophobic compounds in garlic: Allicin, vinyldithiin, ajoene and diallylpolysulfides (Review). Exp Ther Med. 2020;9:1550-3. https://doi.org/10.3892/etm.2019.8388
Sonaji AV, Pradeep AR, Ganesh CS, Sambhaji DG, Anamika, Kumar R, et al. Biological benefits of diallyl disulfide, a garlic-derived natural organic sulfur compound. Journal for Research in Applied Sciences and Biotechnology. 2024;3(1):147-53. https://doi.org/10.55544/jrasb.3.1.24
Bazaraliyeva A, Moldashov D, Turgumbayeva A, Kartbayeva E, Kalykova A, Sarsenova L, et al. Chemical and biological properties of bio-activecompounds from garlic (Allium sativum). Pharmacia. 2022;69(4):955-64. https://doi.org/10.3897/pharmacia.93.e93604
Barbu IA, Cioriță A, Carpa R, Moț AC, Butiuc-Keul A, Pârvu M. Phytochemical characterization and antimicrobial activity of several Allium extracts. Molecules. 2023;28(10):3980. https://doi.org/10.3390/molecules28103980
Bryan-Thomas J, McClear T, Omoregie S. Antimicrobial potential of unstressed and heat stressed Allium sativum. Saudi J Biol Sci. 2023;30(9):103749. https://doi.org/10.1016/j.sjbs.2023.103749
Indira M, Bhuvaneshwari G, Premkumar L, Neelusree P. Antibacterial activity of the Allium sativum crude extract against methicillinresistant Staphylococcus aureus. J Pure Appl Microbiol. 2024;18(2):1297-304. https://doi.org/10.22207/JPAM.18.2.50
Ezeorba TPC, Chukwudozie KI, Ezema CA, Anaduaka EG, Nweze EJ, Okeke ES. Potentials for health and therapeutic benefits of garlic essential oils: recent findings and future prospects. Pharmacological research. Modern Chinese medicine. 2022;3:100075. https://doi.org/10.1016/j.prmcm.2022.100075
Silva JLM, Caetano GM, Garcia GA, Gonçalves TB. Atividade antifúngica do alho (allium sativum) sobre Candida albicans. Rev. Bras. Multidiscip. 2021;24(1):112-26. https://doi.org/10.25061/2527-2675/ReBraM/2021.v24i1.731
Pereira R, Mendes JFS, Fontenelle ROS, Rodrigues THS, Santos HS, Marinho ES, et al. Antifungal activity, antibiofilm, synergism and molecular docking of Allium sativum essential oil against clinical isolates of C. albicans. Res Soc Dev. 2021;10(12):e313101220457. https://doi.org/10.33448/rsd-v10i12.20457
Oliveira EBJ, Cavalcante LBS, Ribeiro DLR. Atividade antimicrobiana do Allium Sativum em combate a Cândida e Staphylococcus Aureus: uma revisão de literatura. Braz J Dev. 2021;7(1):9205-31. https://doi.org/10.34117/bjdv7n1-623
Teixeira A, Sánchez-Hernández E, Noversa J, Cunha A, Cortez I, Marques G, et al. Antifungal Activity of Plant Waste Extracts against Phytopathogenic Fungi: Allium sativum Peels Extract as a Promising Product Targeting the Fungal Plasma Membrane and Cell Wall. Hortic. 2023;9(2):136. https://doi.org/10.3390/horticulturae9020136
Leite AS, Santos JS. Potencial antimicrobiano de Allium sativum L.: uma revisão. Res Soc Dev. 2021;10(14):e108101421699. https://doi.org/10.33448/rsd-v10i14.21699
Agência Nacional de Vigilância Sanitária (BR). Formulário de Fitoterápicos da Farmacopeia Brasileira. 2. ed. Brasília: Anvisa; 2021 [citado 2024 Dez 02]. Disponível em: https://www.gov.br/anvisa/pt-br/assuntos/farmacopeia/formulario-fitoterapico/2024-fffb2-1-er-3-atual-final-versao-com-capa-em-word-2-jan-2024.pdf
Silva A, Cavalcante T, Souza E, Santos F. Allicin in the prophylaxis of cardiovascular diseases: a systematic review. York (UK): PROSPERO; 2022 [citado 2024 Dez 02]. Disponível em: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022385626
Choo S, Chin VK, Wong EH, Madhavan P, Tay ST, Yong PVC, et al. Review: antimicrobial properties of allicin used alone or in combination with other medications. Folia Microbiol (Praha). 2020;65(3):451-65. https://doi.org/10.1007/s12223-020-00786-5
Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil, H. Scoping Reviews (2020). In: Aromataris E, Lockwood C, Porritt K, Pilla B, Jordan Z, editors. JBI Manual for Evidence Synthesis. Adelaide (AU): JBI; 2024. https://doi.org/10.46658/JBIMES-24-09
Mattos SM, Cestari VRF, Moreira TMM. Scoping protocol review: PRISMA-ScR guide refinement. Rev. Enferm. UFPI. 2023;12(1):e3062. https://doi.org/10.26694/reufpi.v12i1.3062
Munn Z, Aromataris E, Tufanaru C, Stern C, Porritt K, Farrow J, et al. The development of software to support multiple systematic review types: the Joanna Briggs Institute System for the Unified Management, Assessment and Review of Information (JBI SUMARI). Int J Evid Based Healthc. 2019;17(1):36-43. https://doi.org/10.1097/XEB.0000000000000152
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71
Drigo RTSC, Becker AC, Riesco MLG, Mascarenhas VHA, Nick JM. Wound-healing properties of Stryphnodendron adstringens (barbatimão) in skin and mucosa injuries: a scoping review protocol. JBI Evid Synth. 2024;22(8):1610-6. https://doi.org/10.11124/JBIES-23-00127
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