Abstract
Objective: To analyze the events supposedly attributable to vaccination or immunization (ESAVI) associated with the Diphtheria-Tetanus Vaccine, Adult Diphtheria-Tetanus-Pertussis Vaccine (Tdap), Hepatitis B, and Influenza vaccines and their severity in pregnant women in Minas Gerais. Methods: Epidemiological, time series study on ESAVI registered in the Information System of the Brazilian National Immunization Program from 2015 to 2020. Four hundred and nine ESAVI were analyzed in pregnant women according to the kind of event, need for medical care, and evolution of the case. Results: The Tdap vaccine showed a higher proportion of ESAVI in this period (56.86%), followed by the Hepatitis B vaccine (29.41%), Influenza vaccine (20.04%), and adult Diphtheria-Tetanus Vaccine (16.00%). Local manifestations were more prevalent, and pain at the injection site was mostly reported. Notably, pregnant women vaccinated with the Adult Diphtheria-Tetanus-Pertussis Vaccine (Tdap) and / or with Hepatitis B vaccine had a higher proportion of events classified as Immunization Error. There was a significant trend towards an increase in the rate of ESAVI because of the Diphtheria-Tetanus Vaccine (p=0.024). Conclusion: The ESAVI incidence rate during pregnancy was low and there was no increase in the risk of pregnant women presenting any serious adverse event after the administration of the recommended vaccines during pregnancy.
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