Low molecular weight heparin on tissue injuries healing: systematic review protocol
PDF
PDF (Português (Brasil))
HTML
HTML (Português (Brasil))
EPUB
EPUB (Português (Brasil))
AUDIO
AUDIO (Português (Brasil))

Keywords

Heparina de Baixo Peso Molecular
Ferimentos e Lesões
Enfermagem Heparin, Low-Molecular-Weight
Wounds and Injuries
Nursing

PlumX Metrics

Abstract

Objective: to investigate the effectiveness of low molecular weight heparin in tissue Injury healing. Method: a systematic review will be carried out of the literature conducted by recommendations of Joanna Briggs Institute (JBI) and PRISMA checklist extension for Systematic Reviews (Reporting Items for Systematic Reviews and Meta-Analyses). Data basis MEDLINE (via PubMed), Embase, LILACS, CINAHL, Scopus e Web of Science. Research question: Do patients with lesions in cutaneous tissue using low molecular weight heparin present Improvement in healing compared to conventional therapies? Inclusion Criteria: Randomized and almost experimental clinical trials that evaluate the use of Low Molecular Weight Heparin in the healing of injuries in 18-year-old or over humans with tissue injuries.

https://doi.org/10.17665/1676-4285.20246759
PDF
PDF (Português (Brasil))
HTML
HTML (Português (Brasil))
EPUB
EPUB (Português (Brasil))
AUDIO
AUDIO (Português (Brasil))

References

Lima NBA de, Agra G, Sousa ATO de, Gouveia B de LA. Sociodemographic, clinical and therapeutic profile of patients with acute and chronic wounds. Rev Enferm UFPE [Internet]. 2016 [cited 2023 set 24];127(10):2005-17. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1362991

Rosa C da, Bueno IL, Quaresma ACM, Longato GB. Healing potential of propolis in skin wounds evidenced by clinical studies. Pharmaceuticals. 2022;15(9):1143. https://doi.org/10.3390/ph15091143

Eming SA, Krieg T, Davidson JM. Inflamação no reparo de feridas: mecanismos moleculares e celulares. JID [Internet]. 2007 [cited 2022 jan 29];127(3):514-25. Available from: https://www.scielo.br/j/rbcf/a/HXZMLDrTL5B7mrRRqSsbtmh/?format=pdf&lang=pt

Campo C, Molinari JF, Ungo J, Ahmed T. Molecular-weight-dependent effects of nonanticoagulant heparins on allergic airway responses. Journal of applied physiology [Internet]. 1999 [cited 2022 jan29];86(2):549-57. https://doi.org/10.1152/jappl.1999.86.2.549

Su N, Tong N, Du L, Wu B, Xu T. Heparin and related substances for treating diabetic foot ulcers. The Cochrane Database of Systematic Reviews. 2017;12:1-3. https://doi.org/10.1002/10.1152/jappl.1999.86.2.549

Olczyk P, Mencner L, Komosinska-Vassev K. The role of the extracellular matrix components in cutaneous wound healing. Biomed Res. Int. 2014;747584. https://doi.org/10.1155/2014/747584

Saliba JMJ. Heparin in the treatment of burns: a review. Burns. 2001;27(4):349-58. https://doi.org/10.1016/s0305-4179(00)00130-3

Durmaz CE, Ozkan A, Senel B, Uyar, H A. Comparison of effects of unfractionated heparin and low molecular weight heparin on skin wound healing of rats. Acta Cir Bras. 2012;27:639-44. https://doi.org/10.1590/S0102-86502012000900009

Uraloğlu M, Livaoğlu M, Agdoğan Ö, Ersöz Ş, Karaçal Ü. The effect of low molecular weight heparin on salvaging the zone of stasis in an experimental burn model. Turk J Med Sci. 2018;48(3):653-60. https://doi.org/10.3906/sag-1710-73

Zhang L, Ma Y, Pan X, Chen S, Zhuang H, Wang S. A composite hydrogel of chitosan/heparin/poly (γ-glutamic acid) loaded with superoxide dismutase for wound healing. Carbohydr Polym. 2018;180:168-74. https://doi.org/10.1016/j.carbpol.2017.10.036

Cen Y, Luo P, Yan X. The effect of heparin on the deep second-degree burn in scalded rats. Chin J Burns [Internet]. 2001 [cited 2022 jan 29];17(3):174-76. Available from: https://europepmc.org/article/med/11876937

Kweon DK, Song SB, Park YY. Preparation of water-soluble chitosan/heparin complex and its application as wound healing accelerator. Biomaterials. 2003;24(9):1595-601. https://doi.org/10.1016/s0142-9612(02)00566-5

Manzoor S, Ahmad Khan FA, Muhammad S, Qayyum R, Muhammad I, Nazir U, et al. Comparative study of conventional and topical heparin treatment in second degree burn patients for burn analgesia and wound healing. Burns. 2019;15(2):379-386. https://doi.org/10.1016/j.burns.2018.05.010

Barretto MGP, Costa MDGNF, Serra MCDVF, Afiune JB, Praxedes HEP, Pagani E. Comparative study of conventional and topical heparin treatments for burns analgesia. Revista da Associação Médica Brasileira [Internet]. 2010 [cited 2022 jan 29];56(1):51-55. Available from:

https://www.scielo.br/j/ramb/a/Sksf4xgYqyGXtXMp3nXd5nq/?format=pdf&lang=en

Manzoor S, Khan FA, Muhammad S, Qayyum R, Muhammad I, Nazir U, Bashir M M. Comparative study of conventional and topical heparin treatment in second degree burn patients for burn analgesia and wound healing. Burns. 2019;45(2):379-86. https://doi.org/10.1016/j.burns.2018.05.010

Young E. The anti-inflammatory effects of heparin and related compounds. Thrombosis research. 2008;122(6):743-752. https://doi.org/10.1016/j.thromres.2006.10.026

Vijayakumar C, Prabhu R, Velan MS, Krishnan VM, Kalaiarasi R, Swetha T. Role of heparin irrigation in the management of superficial burns with special reference to pain relief and wound healing: a pilot study. Cureus [Internet]. 2018 [cited 2022 jan 29];10(8):e3157. Available from: https://www.cureus.com/articles/14087-role-of-heparin-irrigation-in-the-management-of-su%20perficial-burns-with-special-reference-to-pain-relief-and-wound-healing-a-pilot-study#!/

Moraes EB de. Protocolos de Revisão. Online Braz J Nurs. 2022; 21 Suppl 1:e20226585. https://doi.org/10.17665/1676-4285.20226585

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. International Journal of Surgery. 2021;88:105906. https://doi.org/10.1016/j.ijsu.2021.105906

Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L. Chapter 3: Systematic reviews of effectiveness. Aromataris E, Munn, editors. Joanna Briggs Institute Reviewer's Manual [Internet]. Adelaide: JBI; 2017 [cited 2022 jan 29]. Available from: https://jbi-global-wiki.refined.site/space/MANUAL/4688621/Chapter+3%3A+Systematic+reviews+of+effectiveness

Albuquerque R de S. Terapia Por Pressão Negativa (TPN) vs. Terapia Convencional em Ferimentos Complexos - Revisão sistemática [trabalho de conclusão na internet]. Salvador: Faculdade de Medicina da Bahia, Universidade Federal da Bahia; 2017 [cited 2023 set 24]. Available from: https://repositorio.ufba.br/handle/ri/36208

Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097

Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L. Systematic reviews of effectiveness In: Aromataris E, Lockwood C, Porritt K, Pilla B, Jordan Z, editors. JBI Manual for Evidence Synthesis [Internet]. Adelaide: JBI; 2020 [cited 2023 set 24];3. Available from: https://synthesismanual.jbi.global/. https://doi.org/10.46658/JBIMES-20-04

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2024 Array