Abstract
Objective: to analyze the therapeutic effectiveness of convalescent plasma used in patients with confirmed COVID-19 diagnosis. Method: systematic review for health technology assessment to answer the PICO question: Is convalescent plasma effective in reducing the viral load of patients diagnosed with SARS-CoV-2 (COVID-19) when compared to not using plasma? A systematic search was performed in Pubmed/Medline, BVS, Embase, CINAHL, LILACS, Cochrane and Google Scholar databases. The initial screening of titles and abstracts will be independently assessed by two reviewers. To assess the risk of bias in systematic reviews, AMSTAR-2 will be used, and to assess the quality of evidence, GRADE will be used.
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