Resumo
Objetivo: Identificar a associação de fatores sociodemográficos e clínicos com a evolução clínica de pessoas idosas hospitalizadas em UTI no estado do Paraná, segundo a disponibilidade vacinal contra Covid-19. Método: Estudo observacional analítico, de base populacional, com dados secundários de idosos hospitalizados por COVID-19 em UTI. As razões de chances condicionais foram estimadas, a homogeneidade entre estratos foi avaliada pelo teste de Breslow-Day (5%), e a independência condicional pelo teste de Mantel-Haenszel, com estimativa da razão de chances comum. Resultados: Associaram-se a maiores chances de alta hospitalar: faixa etária (OR = 1,97), sexo feminino (OR = 1,20) e cor/raça branca (OR = 1,22). Pessoas idosas com grau de escolaridade ≤ 9 anos de estudo (OR = 0,63), com fatores de risco (OR = 0,69), diabetes (OR = 0,82), imunodeficiência (OR = 0,57), doença hepática (OR = 0,50), doença hematológica (OR = 0,56), pneumopatia (OR = 0,61) e uso de suporte ventilatório (OR = 0,30) apresentaram menores chances de alta hospitalar. Conclusão: A vacinação associou-se a maiores chances de alta hospitalar segundo faixa etária, sexo, cor da pele branca e maior escolaridade. Comorbidades como diabetes mellitus, imunodeficiência, doença hepática, pneumopatias e uso de suporte ventilatório reduziram essa chance.
Referências
World Health Organization. Q&A on coronaviruses (Covid-19) [Internet]. Geneva: WHO; 2020 [citado 2025 Jan 10]. Disponível em: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/q-a-coronaviruses.
World Health Organization. Coronavirus (Covid-19) Dashboard [Internet]. Geneva: WHO; 2023 [citado 2025 Jul 25]. Disponível em: https://covid19.who.int/.
Maciel EL, Jabor P, Goncalves Júnior E, Tristão-Sá R, Lima R de CD, Reis-Santos B, et al. Factors associated with COVID-19 hospital deaths in Espírito Santo, Brazil, 2020. Epidemiol. Serv. Saúde. 2020;29(4):e2020413. https://doi.org/10.1590/s1679-49742020000400022.
Fhon JRS, Silva LM, Leitón-Espinoza ZE, Matiello F de B, Araujo JS, Rodrigues RAP. Hospital care for elderly COVID-19 patients. Rev Lat Am Enfermagem. 2020;28:e3396. https://doi.org/10.1590/1518-8345.4649.3396. PMID: 33174997.
Cavalcanti BRV da S, Marques AP de O, Marques AP de O, Borba AK de OT, Borba AK de OT, Bezerra AE, et al. Fenótipos da Pandemia por coronavírus em idosos. Braz. J. Hea. Rev. 2021;4(4):17154-9. https://doi.org/10.34119/bjhrv4n4-217.
Pan American Health Organization. People over 60 have been hardest hit by COVID-19 in the Americas [Internet]. Washington (DC): OPAS; 2020 [citado 2025 Dez 01]. Disponível em: https://www.paho.org/en/news/30-9-2020-people-over-60-have-been-hardest-hit-covid-19-americas.
Sousa AH da S, Martins SB, Cortez ACL. Influência das comorbidades na saúde dos idosos frente à pandemia da Covid-19: uma revisão integrativa. Res Soc Dev. 2021;10(17):e199101724678. https://doi.org/10.33448/rsd-v10i17.24678.
Bex S, Guinness L, Gaudet-Blavignac C, Martin JH, Stirnemann J, Agoritsas T, et al. Association between critical care occupancy and code status decisions during resource scarcity: a retrospective cohort study. BMC Med Ethics. 2025;26(1):156. https://doi.org/10.1186/s12910-025-01299-x. PMID: 41184990.
Jain S, Valley TS. Who Receives ICU Care during Times of Strain? Triage and the Potential for Racial Disparities. Ann Am Thorac Soc. 2022;19(12):1973-4. https://doi.org/10.1513/AnnalsATS.202209-766ED. PMID: 36454169.
Mendes TO, Somensi RM, Santos RK, Silva AM, Pires RN, Caregnato RCA, et al. COVID-19 and demand for nursing work in intensive care units: retrospective cohort. Online Braz J Nurs. 2024;23:e20246775. https://doi.org/10.17665/1676-4285.20246775.
Marques FRDM, Laranjeira C, Carreira L, Gallo AM, Baccon WC, Paiano M, et al. Illness Experiences of Brazilian People Who Were Hospitalized Due to COVID-19 and Faced Long COVID Repercussions in Their Daily Life: A Constructivist Grounded Theory Study. Behav Sci (Basel). 2023;14(1):14. https://doi.org/10.3390/bs14010014. PMID: 38247666.
Pesce GB, Covre ER, Souza FCS, Marques FRDM, Salci MA, Vissoci JRN, et al. Aging as an aggravating factor of Long Covid: an integrative review. Rev enferm UFPE on line. 2024;18(1):e257702. https://doi.org/10.5205/1981-8963.2024.257702.
Ferreira LS, Darcie Marquitti FM, Paixão da Silva RL, Borges ME, Ferreira da Costa Gomes M, Cruz OG, et al. Estimating the impact of implementation and timing of the COVID-19 vaccination programme in Brazil: a counterfactual analysis. Lancet Reg Health Am. 2023;17:100397. https://doi.org/10.1016/j.lana.2022.100397. PMID: 36439909.
Ministério da Saúde (BR). Profissionais de saúde e pessoas idosas institucionalizados serão os primeiros a receber doses de vacina contra a Covid-19 [Internet]. Brasília: Ministério da Saúde; 2021 [citado 2025 Mar 17]. Disponível em: https://www.gov.br/saude/pt-br/assuntos/noticias/2021/janeiro/profissionais-de-saude-e-idosos-institucionalizados-serao-os-primeiros-a-receber-doses-de-vacina-contra-a-covid-19.
Victora PC, Castro PMC, Gurzenda S, Medeiros AC, França GVA, Barros PAJD. Estimating the early impact of vaccination against COVID-19 on deaths among elderly people in Brazil: Analyses of routinely-collected data on vaccine coverage and mortality. EClinicalMedicine. 2021;38:101036. https://doi.org/10.1016/j.eclinm.2021.101036. PMID: 34308302.
Xing Y, Bahl A. Waning Protection Against Severe COVID-19 Following Vaccination: A Longitudinal IPTW Analysis of Emergency Department Encounters. Infect Dis Rep. 2025;17(6):142. https://doi.org/10.3390/idr17060142. PMID: 41283346.
Rojas-Castro M, Verdasca N, Monge S, De Mot L, Trobajo-Sanmartín C, Duffy R, et al. COVID-19 Vaccine Effectiveness Against Hospitalization in Older Adults, VEBIS Hospital Network, Europe, September 2024-May 2025. Influenza Other Respir Viruses. 2025;19(11):e70191. https://doi.org/10.1111/irv.70191. PMID: 41290396.
Maleki B, Sadeghian AM, Ranjbar M. Impact of vaccination against SARS-CoV-2 on mortality risk, ICU admission rate, and hospitalization length in hospitalized COVID-19 patients: a cross-sectional study. BMC Infect Dis. 2025;25(1):144. https://doi.org/10.1186/s12879-025-10530-4. PMID: 39885405.
Carazo S, Skowronski DM, Brousseau N, Guay C, Sauvageau C, Racine É, et al. Monovalent mRNA XBB.1.5 vaccine effectiveness against COVID-19 hospitalization in Quebec, Canada: Impact of variant replacement and waning protection during 10-month follow-up. PLoS One. 2025;20(6):e0325269. https://doi.org/10.1371/journal.pone.0325269. PMID: 40460407.
Instituto Brasileiro de Geografia e Estatística. Projeções da População [Internet]. Rio de Janeiro: IBGE; 2024 [citado 2025 Set 05]. Disponível em: https://www.ibge.gov.br/estatisticas/sociais/populacao/9109-projecao-da-populacao.html?utm_source=projecao&utm_medium=popclock&utm_campaign=projecao-2018&t=resultados.
Strengthening the Reporting of Observational Studies in Epidemiology. STROBE Checklists [Internet]. Bern: STROBE; 2022 [citado 2025 Maio 12]. Disponível em: https://www.strobe-statement.org/checklists/.
Open DataSUS [Internet]. Brasília: Ministério da Saúde; 2022 [citado 2025 Dez 21]. Disponível em: https://opendatasus.saude.gov.br/dataset/srag-2021-e-2022.
Fedele G, Palmieri A, Onder G. The immune response to SARS-CoV-2 vaccination in older people. Lancet Healthy Longev. 2023;4(5):e177-8. https://doi.org/10.1016/S2666-7568(23)00060-0. PMID: 37148886.
Lavista Ferres JM, Richardson BA, Weeks WB. Association of COVID-19 vaccination prioritization and hospitalization among older Washingtonians. J Am Geriatr Soc. 2021;69(10):2780-2782. https://doi.org/10.1111/jgs.17315. PMID: 34106460.
Zhang L, Jiang L, Tian T, Li W, Pan Y, Wang Y. Efficacy and Safety of COVID-19 Vaccination in Older Adults: A Systematic Review and Meta-Analysis. Vaccines (Basel). 2022;11(1):33. https://doi.org/10.3390/vaccines11010033. PMID: 36679878.
Yang XH, Bao WJ, Zhang H, Fu SK, Jin HM. The Efficacy of SARS-CoV-2 Vaccination in the Elderly: A Systemic Review and Meta-analysis. J Gen Intern Med. 2023:1-9. https://doi.org/10.1007/s11606-023-08254-9. PMID: 37266884.
Shabu A, Nishtala PS. Safety outcomes associated with the moderna COVID-19 vaccine (mRNA-1273): a literature review. Expert Rev Vaccines. 2023;22(1):393-409. https://doi.org/10.1080/14760584.2023.2209177. PMID: 37133747.
Lopez Bernal J, Andrews N, Gower C, Robertson C, Stowe J, Tessier E, et al. Effectiveness of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines on covid-19 related symptoms, hospital admissions, and mortality in older adults in England: test negative case-control study. BMJ. 2021;373:n1088. https://doi.org/10.1136/bmj.n1088. PMID: 33985964.
Salinas-Martínez AM, Rodríguez-Vidales EP, Garza-Carrillo D, Robles-Rodríguez OA, Oca-Luna RM, Marroquín-Escamilla AR. Comparison of the effectiveness of four SARS-COV-2 v accines in Nuevo Leon, Mexico: A test-negative control study. Aten Primaria. 2023;55(5):102606. https://doi.org/10.1016/j.aprim.2023.102606. PMID: 37002983.
Pimentel MH, Pereira F, Teixeira C. Impacto da covid-19 em idosos institucionalizados em estruturas residenciais para pessoas idosas. Revista INFAD de Psicología. 2021;1(1):477-90. https://doi.org/10.17060/ijodaep.2021.n1.v1.2129.
Hawkins RB, Charles J, Mehaffey JH. Socio-economic status and COVID-19-related cases and fatalities. Public Health. 2020;189:129-134. https://doi.org/10.1016/j.puhe.2020.09.016. PMID: 33227595.
van Diepen S, McAlister FA, Chu LM, Youngson E, Kaul P, Kadri SS. Association Between Vaccination Status and Outcomes in Patients Admitted to the ICU With COVID-19. Crit Care Med. 2023;51(9):1201-1209. https://doi.org/10.1097/ccm.0000000000005928. PMID: 37192450.
Summan A, Nandi A, Wahl B, Carmona S, Ongarello S, Vetter B, et al. Estimates of hospitalisations and deaths in patients with COVID-19 associated with undiagnosed diabetes during the first phase of the pandemic in eight low-income and middle-income countries: a modelling study. EClinicalMedicine. 2024;70:102492. https://doi.org/10.1016/j.eclinm.2024.102492. PMID: 38481788.
Fortuna D, Caselli L, Berti E, Moro ML. Direct impact of 2 years of COVID-19 on chronic disease patients: a population-based study in a large hard-hit Italian region. BMJ Open. 2023;13(10):e073471. https://doi.org/10.1136/bmjopen-2023-073471. PMID: 37899159.
Nham E, Kim Y, Jung J, Kim DW, Jang H, Hyun H, et al. COVID-19 Vaccination Rates in Patients With Chronic Medical Conditions: A Nationwide Cross-Sectional Study. J Korean Med Sci. 2022;37(45):e325. https://doi.org/10.3346/jkms.2022.37.e325. PMID: 36413798.
Fu L, Fei J, Xu S, Xiang H, Xiang Y, Hu B, et al. Liver Dysfunction and Its Association with the Risk of Death in COVID-19 Patients: A Prospective Cohort Study. J Clin Transl Hepatol. 2020;8(3):246-254. https://doi.org/10.14218/JCTH.2020.00043. PMID: 33083246.
Naimi A, Yashmi I, Jebeleh R, Imani Mofrad M, Azimian Abhar S, Jannesar Y, et al. Comorbidities and mortality rate in COVID-19 patients with hematological malignancies: A systematic review and meta-analysis. J Clin Lab Anal. 2022;36(5):e24387. https://doi.org/10.1002/jcla.24387. PMID: 35385130.
Acar IH, Guner SI, Ak MA, Gocer M, Ozturk E, Atalay F, et al. Impact of COVID-19 on Outcomes of Patients with Hematologic Malignancies: A Multicenter, Retrospective Study. Mediterr J Hematol Infect Dis. 2022;14(1):e2022074. https://doi.org/10.4084/MJHID.2022.074. PMID: 36425152.
Pagano L, Salmanton-García J, Marchesi F, Busca A, Corradini P, Hoenigl M, et al. COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA). J Hematol Oncol. 2021;14(1):168. https://doi.org/10.1186/s13045-021-01177-0. PMID: 34649563.
Vijenthira A, Gong I, Fox TA, Booth S, Cook G, Fattizzo B, et al. Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients. Blood. 2020;136(25):2881-2892. https://doi.org/10.1182/blood.2020008824. PMID: 33113551.
Zhang J, Ma Y, To WL, Chow S, To Tang H, Wong HK, et al. Impact of COVID-19 infection on mortality, diabetic complications and haematological parameters in patients with diabetes mellitus: a systematic review and meta-analysis. BMJ Open. 2025;15(3):e090986. https://doi.org/10.1136/bmjopen-2024-090986. PMID: 40147989.
Moraes EV de, Pires MC, Costa AAA, Nunes AGS, de Amorim CL, Manenti ERF, et al. Comprehensive statistical analysis reveals significant benefits of COVID-19 vaccination in hospitalized patients: propensity score, covariate adjustment, and feature importance by permutation. BMC Infect Dis. 2024;24(1):1052. https://doi.org/10.1186/s12879-024-09865-1. PMID: 39333931.
Turtle L, Thorpe M, Drake TM, Swets M, Palmieri C, Russell CD, et al. Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study. PLoS Med. 2023;20(1):e1004086. https://doi.org/10.1371/journal.pmed.1004086. PMID: 36719907.
Uzun O, Akpolat T, Varol A, Turan S, Bektas SG, Cetinkaya PD, et al. COVID-19: vaccination vs. hospitalization. Infection. 2022;50(3):747-752. https://doi.org/10.1007/s15010-021-01751-1. PMID: 34984646.
Doti JL. The impact of vaccinations and chronic disease on COVID death rates. J Bioecon. 2023;25(3):239-269. https://doi.org/10.1007/s10818-023-09339-5.
Cunha LL, Perazzio SF, Azzi J, Cravedi P, Riella LV. Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response. Front Immunol. 2020;11:1748. https://doi.org/10.3389/fimmu.2020.01748. PMID: 32849623.
Suthar AB, Wang J, Seffren V, Wiegand R, Griffing S, Zell E. Public health impact of covid-19 vaccines in the US: observational study. BMJ. 2022;377:e069317. https://doi.org/10.1136/bmj-2021-069317. PMID: 35477670.

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2026 Online Brazilian Journal of Nursing

