Abstract
Objective: To describe the effects of low-level laser therapy observed in individuals with diabetes mellitus. Method: A retrospective documentary study conducted at a reference outpatient health care complex in the state of Rio de Janeiro. Data collection took place between May and July 2025 through electronic medical records, from which information regarding laser therapy indications, dosimetry, treatment duration, and clinical progression was extracted. Data were analyzed using simple descriptive statistics. Results: A total of 402 low-level laser therapy sessions were performed in 52 patients, with an annual mean of 133 applications. Of these, 361 (89.8%) corresponded to the control and adjunctive treatment of lower-limb infections, mainly onychomycosis (n=285; 70.9%), tinea pedis (n=61; 15.2%), and tissue repair (n=27; 6.7%), over 24 months of follow-up. Conclusion: The observed effects of low-level laser therapy were favorable across different clinical outcomes, including improvement of fungal infections such as onychomycosis and tinea pedis, ulcer healing, edema reduction, and pain relief.
References
Oliveira GF de, Casimiro MRA, Souza AC de, Santos AKA dos, Gonçalves AG, Batista MES, et al. Terapia a laser de baixa intensidade no tratamento do pé diabético: impactos na cicatrização e o papel do enfermeiro. Rev Contemp. 2025;5(8):e8899. https://doi.org/10.56083/RCV5N8-081
Forti AC e, Oires AC, Pittito B de A, Gerchman F, Oliveira JEP de, Zajdenverg L, et al., organizadores. Diretrizes da Sociedade Brasileira de Diabetes 2019 – 2020 [Internet]. São Paulo: CLANNAD; 2019 [citado 2025 Ago 18]. Disponível em: https://www.diabetes.org.br/profissionais/images/DIRETRIZES-COMPLETA-2019- 2020.pdf
Van Netten JJ, Bus SA, Apelqvist J, Lipsky BA, Hinchliffe RJ, Game F, et al. International Working Group on the Diabetic Foot. Definitions and criteria for diabetic foot disease. Diabetes Metab Res Rev. 2020;36(Suppl)1:e3268. https://doi.org/10.1002/dmrr.3268. PMID: 31943705
Brito JFP, Bezerra SMG, Oliveira AC, Sousa LS, Silva EB, Rocha ESB. Sensorimotor alterations and associated factors in diabetes mellitus patients Texto Contexto Enferm. 2020;29:e20180508. https://doi.org/10.1590/1980-265X-TCE-2018-0508
Brandão MGSA, Ximenes MAM, Ramalho A de O, Veras VS, Barros LM, Araújo TM de. Efeitos da laserterapia de baixa intensidade na cicatrização de úlceras nos pés em pessoas com diabetes mellitus. ESTIMA, Braz J Enterostomal Ther. 2020;18:e0320. https://doi.org/10.30886/estima.v18.844_PT
Lucena AF, Bavaresco T, Menegon DB, Schneider SMB, Medeiros RM, Souza CMB. Laser in wounds: knowledge translation to an effective and innovative nursing practice. Rev Gaúcha Enferm. 2021;42:e20200396. https://doi.org/10.1590/1983-1447.2021.20200396. PMID: 34755805
Blascovich HB, Nogueira AG, Costa ACPJ, Pascoal LM, Araújo TM. Parâmetros e Protocolos da Laserterapia utilizados no tratamento de feridas diabéticas. Rev Enferm Atual In Derme [Internet]. 2022 [citado 2025 Ago 18];96(38):e21222. Disponível em: https://teste.revistaenfermagematual.com/index.php/revista/article/view/1321/1322
Garapati C, Boddu SHS, Jacob S, Ranch KM, Patel C, Babu RJ, et al. Photodynamic therapy: A special emphasis on nanocarrier-mediated delivery of photosensitizers in antimicrobial therapy. Arab J Chem. 2023;16:104583. https://doi.org/10.1016/j.arabjc.2023.104583
Ferreira LPS, Pérez Júnior EF, Pires A da S, Gonçalves FG de A, Nunes AS, Coutinho VL, et al. O uso da laserterapia de baixa intensidade na prática do enfermeiro: uma revisão integrativa. Res Soc Dev. 2021;10(14):e422101422325. https://doi.org/10.33448/rsd-v10i14.22325
Creswell JW, Creswell JD. Research design: qualitative, quantitative, and mixed methods approaches. 6th ed. Thousand Oaks: SAGE Publications; 2023.
Frigo FD, Pérez Júnior EF, Pires AS, Coutinho VL, Gonçalves FGA, Lima JA. Low intensity laser therapy with photodynamic therapy in the treatment of onychomycosis. Rev Enferm UERJ. 2022;30(1):e64955. https://doi.org/10.12957/reuerj.2022.64955
Pérez Júnior EF, Paula CM, Pires A da S, Nunes A'S, Gonçalves FG de A, Tavares KFA. Laser therapy and topical drug treatment for onychomycosis in people with diabetes: A case series study. Rev Enferm UFSM. 2023;13:e31:1-16. https://doi.org/10.5902/2179769274448
Lipner SR, Scher RK. Onychomycosis: Treatment and prevention of recurrence. J Am Acad Dermatol. 2019;80(4):853-867. https://doi.org/10.1016/j.jaad.2018.05.1260. PMID: 29959962
Gupta AK, Stec N, Summerbell RC, Shear NH, Piguet V, Tosti A, et al. Onychomycosis: a review. J Eur Acad Dermatol Venereol. 2020;34(9):1972-1990. https://doi.org/10.1111/jdv.16394. PMID: 32239567
Santos CMD, Rocha RBD, Hazime FA, Cardoso VS. A Systematic Review and Meta-Analysis of the Effects of Low-Level Laser Therapy in the Treatment of Diabetic Foot Ulcers. Int J Low Extrem Wounds. 2021;20(3):198-207. https://doi.org/10.1177/1534734620914439. PMID: 32394760
Huang J, Chen J, Xiong S, Huang J, Liu Z. The effect of low-level laser therapy on diabetic foot ulcers: A meta-analysis of randomised controlled trials. Int Wound J. 2021;18(6):763-776. https://doi.org/10.1111/iwj.13577. PMID: 33751853
Godoy LMP de, Godoy HJP de, Godoy JMP de. Cross-Over Study Evaluating Photobiomodulation in Pain Control in the Lower Limb. Cureus. 2024;19;16(7):e64914. https://doi.org/10.7759/cureus.64914. PMID: 39035599
Bavaresco T, Osmarin VM, Pires AU, Moraes VM, Lucena M de F. Terapia a laser de baixa potência na cicatrização de feridas. Rev Enferm UFPE. 2019;13:1,216-26. https://doi.org/10.5205/1981-8963-v13i1a235938p216-226-2019
Navarro-Bielsa A, Gracia-Cazaña T, Robres P, Lopez C, Calvo-Priego MD, Aspiroz C, Gilaberte Y. Combination of Photodynamic Therapy and Oral Antifungals for the Treatment of Onychomycosis. Pharmaceuticals (Basel). 2022;7;15(6):722. https://doi.org/10.3390/ph15060722. PMID: 35745641
Fallahi F, Mostafavinia A, Sharifi Z, Shalmani LM, Amini A, Ahmadi H, et al. Efeitos da fotobiomodulação na função mitocondrial em células-tronco derivadas de tecido adiposo diabético in vitro. Spectrochim Acta A Mol Biomol Spectrosc. 2023;285:15,121835. https://doi.org/10.1016/j.saa.2022.121835. PMID: 36116412

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