SCOPING REVIEW

 

Effects of assisted therapy with animals for pain management: systematic review protocol

 

Antonio Venâncio Sant’ Anna1, Luana Vieira Toledo1, Patrícia de Oliveira Salgado1, Cissa Azevedo2, Denismar Alves Nogueira3, Caroline de Castro Moura1

 

1Federal University of Viçosa, Viçosa, MG, Brazil

2University of de São João Del Rei, São João Del Rei, MG, Brazil

3Federal University of Alfenas, Alfenas, MG, Brazil

 

ABSTRACT

Objective: To evaluate the existing randomized clinical trials in the literature on the effects of Animal Assisted Therapy on pain management in people with pain when compared to conventional treatment or other non-pharmacological interventions. Method: Systematic Review, reported according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). The protocol was registered at the International Prospective Register of Systematic Reviews (PROSPERO). The search will be carried out in various sources of information, combining the descriptors ‘Animal Assisted Therapy’, ‘Pain Management’, and ‘Controlled Clinical Trial’ and their variations. Only randomized clinical trials will be included, and results will be managed in EndNote and Rayyan software. The assessment of bias risk will be carried out by the Cochrane Collaboration Risk of Bias 2 tool, and the assessment of the certainty of evidence by the Grading of Recommendations, Assessment, Development, and Evaluation. If possible, a meta-analysis will be performed to determine the effect of Assisted Therapy with Animals on pain intensity.

 

Keywords: Assisted Therapy with Animals; Pain Management; Systematic Review.

 

INTRODUCTION

Pain is one of the main stressors present in people who seek or are in a health unit. It interferes with the respiratory, hemodynamic, physical and metabolic systems; and can cause damage to sleep, physical wear and fatigue. This substantially compromises the quality of life of people and may promote less motivation in cooperation with treatment(1).

Pharmacological treatment is one of the main pillars of pain management(2), based on analgesics. However, despite being a relatively effective solution, it may also present unwanted side effects(1), such as nausea, vomiting, respiratory depression, and hallucinations(2). In addition, pain is considered a multidimensional condition, not restricted only to the physiological part; it also involves affective, emotional, spiritual, psychological, and social variables(1).

Therefore, health professionals must be attentive to the multidimensionality of pain in their clinical practice, adopting systematic evaluation techniques that allow the understanding of the whole and not only of the parts. It leads to the construction of a more accurate diagnosis, brings greater specificity to the interventions adopted, and reveals the professional's accountability to the patient with pain, which can provide better assistance and a more humanized approach(1).

Nowadays, seeking a better offer of the services provided, health managers and professionals have increasingly been concerned with the theme of pain and its variables. Above all, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) includes pain relief as an item to be evaluated in the hospital accreditation process(1). Thus, there is a greater demand for effective strategies and potentializing behaviors adopted by health professionals, which can be used synergistically with traditional forms of treatment(3).

One resource that has proved to be very promising and whose practice has already been regulated in several countries is Animal Assisted Therapy (AAT). It is defined as a structured, non-pharmacological therapeutic approach involving trained professionals who use the animal as part of the work process to intervene in the social, physical, emotional, and cognitive aspects of the people involved(4).

The application of AAT has been positively reported in the literature, in which the reduction of insomnia and chronic pain is observed in the elderly (5); improvement of living conditions and the general state of inactivity(5); reduction of symptoms of depression and improvement of cognition and mood in those with Alzheimer's disease (4). The literature also brings that it reduces anxiety in adults and students, helps in the recovery of surveillance after anesthesia, improves the feeling of well-being in children and adolescents with cancer, and motivates physical activity in overweight children(4); it also provides modulation of respiratory and cardiac frequencies, blood pressure and oxygen saturation in children(2). Moreover, it can be configured as a complementary intervention to conventional treatment to control pain in children(6,7) and adolescents(6). However, through prior investigation in national and international sources of information, systematic reviews on the subject were not found with the general population, detailing, for example, the type of disease and the nature of pain in which AAT is most effective, as well as the effects, risks, benefits and their implications in patient care. In addition, among the existing studies, a few have high methodological rigor, making the applicability of therapy controversial(2). Thus, it is necessary to carry out this review, whose general objective will be to evaluate the randomized clinical trials existing in the literature on the effects of AAT on pain management in people with pain when compared to conventional treatment or other non-pharmacological interventions; In addition to identifying in which types of pain the AAT is applied; the instruments used for pain assessment and measurement; the levels of health care in which therapy is performed; the professionals involved in the conduction of therapy; the types of animals used; The risks and benefits of AAT; and the overall effect of AAT on pain intensity.

 

METHOD

 

Protocol and registration

This systematic literature review will be reported according to Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P)(8).

The protocol was entered on the International Prospective Register of Systematic Reviews (PROSPERO) basis under the registration CRD42021269685.

 

Eligibility criteria

 Randomized clinical trials will be included in the systematic review, available in full at reading, of any year or language, which employ the AAT performed with any animal, used alone or in combination with other methods, and implemented exclusively by health professionals. The control group should include conventional routine treatment or other non-pharmacological interventions for pain management.

No limits will be established on gender, age group, or ethnic origin. Studies involving the application of AAT at different levels of health care (primary, secondary, and tertiary) and in other environments will also be considered, provided that there are therapeutic purposes.

Exclusion criteria: Theses, dissertations, editorials, and studies with incomplete data will be considered. Observational studies and reviews will not be included but will be read to identify possible eligible studies.

 

Sources of information

The search for the studies will be carried out in the following sources of information: Medical Literature Analysis and Retrieval System Online (MEDLINE) via PubMed, PubMed Central (PMC), EMBASE (via Embase.com), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), World Health Organization International Clinical Trials Registry Platform (ICTRP), ClinicalTrials.gov (CT.gov), Biblioteca Virtual de Saúde (BVS), Medicina Tradicional, Complementar e Integrativa (MTCI Américas), Web of Science, Scopus, Physiotherapy Evidence Database (PEDro).

For each selected article, abstracts and full texts will be obtained. Reference lists of included studies and systematic reviews will be examined during the review. Even if not published and/or indexed, studies identified by Google Scholar, ClinicalTrials.gov, Brazilian Registry of Clinical Tests (ReBEC), and Brazilian Library of Theses and Dissertations will also be evaluated.

 

Development of the research question

The research question was developed based on the acronym PICO (P– population; I– intervention; C– comparison; O– Outcomes)(9) (Table 1).

 

Table 1 - Development of the research question according to the PICO strategy. Viçosa, MG, Brazil, 2022

PICO

Componentes

Question

What is the effect of AAT (intervention) on pain management (results) in people with pain (population) when compared to conventional treatment or other non-pharmacological interventions (comparison)?

Population

People with pain clinical signs of any age, gender, and ethnicity treated at any level of health care (primary, secondary, tertiary)

Intervention

Therapy with Animals (dogs, cats, horses, snakes, turtles, rodents, guinea pigs, and birds)

Comparator

Conventional routine treatment or other non-pharmacological interventions for pain management

Outcomes

Pain management

Source: Elaborated by the authors, 2022.

 

Search strategy

The search strategy will be developed by two authors with the contribution of a librarian with experience in the health area. The bibliographical research will be repeated immediately after the final analysis to enable the review of new studies and inclusion in this review. The descriptors in Health Sciences (DeCS) /Medical Subject Heading (MeSH) will be used, as well as keywords and free text search terms. All terms will be combined through BOOLEAN and OR operators. Table 2 describes the terms that will be used for the search strategy.

 

Table 2 - Search strategy. Viçosa, MG, Brazil, 2022

  1. Search strategy to locate ‘Assisted Therapy with Animals’

  1. Animal assisted therapy [Mesh]

10. Terapia assistida com animais [DeCS]

2. Animal assisted therapies

11. Terapia com Animais

3. Animal assisted activity

12. Atividade assistida com animais

4. Animal assisted activities

13. Atividades assistidas com animais

5. Animal Facilitated Therapy

14. Terapia facilitada com animais

6. Animal Facilitated Therapies

15. Terapias facilitadas com animais

7. Therapy animals

16. Animais de terapia

8. Animal assisted intervention

17. Intervenção assistida por animais

9. Animal assisted interventions

18. Intervenções assistidas por animais

A. OR/1-18

  1. Search strategy to locate ‘pain’

19. Pain [Mesh]

25. Ache

20. Pain management [Mesh]

26. Aches

21. Pain control

27. Dor [Decs]

22. Pain relief

28. Manejo da dor [DeCs]

23. Acute pain [Mesh]

29. Dor aguda [DeCs]

24. Chronic pain [Mesh]

30. Dor crônica [DeCs]

B. OR/19-30

C. Search strategy to locate ‘Randomized Clinical Trial’

31. Clinical trial

35. Ensaio Clínico Controlado [DeCS]

32. Controlled clinical trial [Mesh]

36. Ensaio Clínico Controlado Aleatório [DeCS]

33. Clinical Study [Mesh]

37. Ensaio Clínico Controlado Randomizado

34. Randomized controlled trial [Mesh]

38. Ensaio Controlado Aleatório

C. OR/31-38

A AND B AND C

Source: Elaborated by the authors, 2022.

 

After completing the Medline research, the research strategy will be adapted to the other databases.

 

Data management

The search will be carried out in the information sources and uploaded to EndNote, reference management software. All results will be inserted into a single folder in this software, and duplicate studies will be identified and removed. After removing duplicates, the search results will be loaded into Rayyan, software that allows selecting articles by titles and abstracts in blind cooperation between reviewers.

 

Process of articles selection

The selection of articles will be done in two stages. The first step will involve reading the titles and abstracts of articles found in each database based on eligibility criteria. In the second stage, the pre-selected articles will be read in full to confirm whether or not they meet the eligibility criteria. In both stages, each article will be independently evaluated by two reviewers. Furthermore, in case of disagreements, a third reviewer will perform a new analysis, and the divergences will be resolved by mutual discussion among all researchers.

 

Data extraction process

Data from the included studies will be extracted independently by two researchers, using a data extraction form, with the following information(10,11) (Table 3):

 

Table 3 - Information to be extracted from the selected articles. Viçosa, MG, Brazil, 2022

 

Study identification

Author

Year of publication of the study

Country of study

Method

Participants

Eligibility Criteria

Clinical condition (time and type of pain)

Scenario

Level of health care where the study was conducted

Design and allocation of the group

Study design

Duration of study

Follow-up groups (experimental group x control group/placebo)

Randomization

Masking of allocation

AT intervention

Professional who carried out the intervention

Animal used, with justification for the choice

Frequency of the sessions

Duration time of each session

Duration time of complete treatment

Authorizations for the use of the animal in the health service

Control group

Type of control (no treatment, standard treatment, placebo)

Description of intervention

Primary outcome

Instrument used for evaluation

Moments of measurement

Other outcomes

Name and definition

Instrument used for evaluation

Moments of measurement

 

Results

Number of participants randomized/allocated per group/analyzed

Details of any missing participants

Basic demographic data for each group

Summary data for each group in each evaluation time

Adverse events

 

Discussion

Interpretation of results

Extension of generalization

Limitations of the study

Suggestions for new studies

 

Conclusion

Main conclusions

Source: Elaborated by the authors, 2022.

 

The authors of the studies may be contacted by e-mail to obtain the missing data.

 

Evaluation of the outcome

The main outcome of the study is pain management. It will be measured by objective methods (physiological parameters – respiratory rate, heart rate, blood pressure, pain threshold measured by an algometer) and subjective (validated uni or multidimensional instruments). The outcome will be evaluated from the results presented by the studies in two moments: immediately before and immediately after the intervention.

 

Assessment of risk of bias

In this study, the bias risk assessment will be performed using the Cochrane Collaboration Risk of Bias – ROB 2.0tool, encompassing three types of randomized clinical trials: parallel controlled, cluster and cross-over(12). Two researchers will independently evaluate the risk of bias, and a third researcher will discuss and resolve the divergences.

 

Data synthesis and analysis

The data can be analyzed quantitatively, through meta-analysis and/or qualitative, through narrative synthesis.

If meta-analysis can be conducted, Stata statistical software will be used for data analysis. The risk odd will be used to estimate dichotomous variables, and the mean difference will be used for continuous variables, with a 95% confidence interval. 5% of significance will be adopted for the hypothesis tests.

The potential heterogeneity between the studies will be examined using of Cochran's Qstatistics(13) and Higgins Method (Statistics I2)(14). Values of 25%, 50%, and 75% for I2 represent low, medium, and high heterogeneity(14). The result will be displayed using a forest graph. If necessary, subgroup analysis will be performed, based on possible factors that can lead to heterogeneity, such as intervention, control, age, treatment duration, and study quality.

 

Evaluation of the quality of evidence

Grading of Recommendations, Assessment, Development and Evaluation (GRADE)(15) will be used to assess the certainty of evidence. This evaluation will be carried out independently by two researchers. A meeting will be held in case of disagreement according to a third researcher.

 

 

CONFLICT OF INTERESTS

The authors have declared that there is no conflict of interests.

 

REFERÊNCIAS

1. Ferrari MFM, Daher DV, Antunes JM, Amim EF, Jesus CM, Geraldo MA. Pain as the fifth vital sign, challenges for its incorporation in health training. REME (Online). 2019;23(e-1233):1-5. https://doi.org/10.5935/1415-2762.20190081

 

2. Zhang Y, Yan F, Li S, Wang Y, Ma Y. Effectiveness of animal-assisted therapy on pain in children: A systematic review and meta-analysis. Int J Nurs Sci (Online). 2021;8(1):30-37. https://doi.org/10.1016/j.ijnss.2020.12.009

 

3. Dalmolin IS, Heidemann ITSB. Integrative and complementary practices in Primary Care: unveiling health promotion. Rev Lat Am Enfermagem (Online). 2020;28(e-3277):1-10. https://doi.org/10.1590/1518-8345.3162.3277

 

4. Mandrá PP, Moretti TCF, Avezum LA, Kuroishi RCS. Animal assisted therapy: systematic review of literature. CoDAS (Online). 2019;31(3):e20180243. https://doi.org/10.1590/2317-1782/20182018243

 

5. Rodrigo-Claverol M, Casanova-Gonzalo C, Malla-Clua B, Rodrigo-Claverol E, Jové-Naval J, Ortega-Bravo M. Animal-Assisted Intervention Improves Pain Perception in Polymedicated Geriatric Patients with Chronic Joint Pain: A Clinical Trial. Int J Environ Res Public Health (Online). 2019;16(16):2843. https://doi.org/10.3390/ijerph16162843

 

6. Feng Y, Lin Y, Zhang N, Jiang X, Zhang L. Effects of Animal-Assisted Therapy on Hospitalized Children and Teenagers: A Systematic Review and Meta-Analysis. J Pediatr Nurs (Online). 2021;60:11-23. https://doi.org/10.1016/j.pedn.2021.01.020

 

7. Charry-Sánchez JDPradill ITalero-Gutiérrez C. Effectiveness of Animal-Assisted Therapy in the Pediatric Population: Systematic Review and Meta-Analysis of Controlled Studies. J Dev Behav Pediatr (Online). 2018;39(7):580-590. https://doi.org/10.1097/DBP.0000000000000594

 

8. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev (Online). 2015;4(1). https://doi.org/10.1186/2046-4053-4-1

 

9. Aslam S, Emmanuel P. Formulating a researchable question: A critical step for facilitating good clinical research. Indian J Sex Transm Dis AIDS (Online). 2010;31(1):47-50. https://doi.org/10.4103/0253-7184.69003

 

10. McGlinchey MP, James J, McKevitty C, Douiri A, McLachlan S, Sacley CM. The effect of rehabilitation interventions on physical function and immobility-related complications in severe stroke - protocol for a systematic review. Syst Rev (Online). 2018;7(197):1-8.: https://doi.org/10.1186/s13643-018-0870-y

 

11. Younas A, Ali P. Five tips for developing useful literature summary tables for writing review articles. Evid Based Nurs (Online). 2021;24(2):32-34. https://doi.org/10.1136/ebnurs-2021-103417

 

12. Higgins JPT, Savovic J, Page MJ, Sterne JAC. Revised Cochrane risk of bias tool for randomized trials (RoB 2.0). Cochrane (Online) [Internet]. 2016 [cited 2021 Ago 15];7(197). Available from: https://www.unisa.edu.au/contentassets/72bf75606a2b4abcaf7f17404af374ad/rob2-0_indiv_main_guidance.pdf

 

13. Lau J, Ioannidis JP, Schmid CH. Quantitative synthesis in systematic reviews. Ann Intern Med AIDS (Online). 1997;127(9):820-826. https://doi.org/10.7326/0003-4819-127-9-199711010-00008

 

14. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med (Online). 2002;21(11):1539-1558. https://doi.org/10.1002/sim.1186

 

15. Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P, Knottnerus A. GRADE guidelines: A new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol (Online). 2011;64(4):380-382. https://doi.org/10.1016/j.jclinepi.2010.09.011

 

Submission: 06/12/2022

Approved: 07/04/2023

 

AUTHORSHIP CONTRIBUTIONS

Project design: Sant’ Anna AV, Toledo LV, Salgado PO, Moura CC

Data collection: Sant’ Anna AV, Toledo LV, Salgado PO, Moura CC

Data analysis and interpretation: Sant’ Anna AV, Toledo LV, Salgado PO, Azevedo C, Nogueira DA, Moura CC

Writing and/or critical review of the intellectual content: Sant’ Anna AV, Toledo LV, Salgado PO, Azevedo C, Nogueira DA, Moura CC

Final approval of the version to be published: Sant’ Anna AV, Toledo LV, Salgado PO, Azevedo C, Nogueira DA, Moura CC

Responsibility for the text in ensuring the accuracy and completeness of any part of the paper: Sant’ Anna AV, Toledo LV, Salgado PO, Azevedo C, Nogueira DA, Moura CC

 

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