Mortality in sickle cell anemia: a retrospective cohort study
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Keywords

Sickle cell anemia
Mortality
Survival
Epidemiology. Anemia falciforme
Mortalidad
Sobrevida
Epidemiología. Anemia Falciforme
Mortalidade
Sobrevida
Epidemiologia.

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Abstract

Objective: To epidemiologically analyze the mortality of the patients with sickle cell anemia in two reference centers for treatment in the state of Mato Grosso do Sul. Method: An epidemiological study with a quantitative approach and of the descriptive and analytical type, by means of a retrospective, individualized cohort design. It will be carried out in two public hospitals of reference for the treatment of Sickle Cell Anemia (SCA) in Mato Grosso do Sul and will use as a unit of analysis individuals diagnosed with SCA followed-up in these services from 1980 to 2018. Expected results: It is expected to historically describe the course of SCA in order to obtain subsidies to verify the outcomes, among them the deaths and their respective causes, to enable strategies for treatment and control of the disease and its complications.

https://doi.org/10.17665/1676-4285.20196233
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References

Piel FB, Steinberg MH, Rees DC. Sickle cell disease. N Engl J Med [Internet]. 2017 [access in 10 feb 2019]; 376(16):[1561-73 pp.]. Available from: https://www.nejm.org/doi/full/10.1056/NEJMra1510865?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed.

Ware RE, de Montalembert M, Tshilolo L, Abboud MR. Sickle cell disease. Lancet [Internet]. 2017 [access in 10 feb 2019]; 390(10091):[311-23 pp.]. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30193-9/fulltext.

McGann PT, Schaefer BA, Paniagua M, Howard TA, Ware RE. Characteristics of a rapid, point‐of‐care lateral flow immunoassay for the diagnosis of sickle cell disease. Am J Hematol [Internet]. 2016 [access in 24 apr 2019] 91(2):[205-10 pp.]. Available from: https://www.sciencedirect.com/science/article/pii/S0140673617301939?via%3Dihub.

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